In recent years, we have developed rapidly, but compared with the imported instruments, our country still has a big gap with the developed countries. But with the arrival of the twelfth five year, the domestic instrument and ushered in a new development opportunity. China started the "national major scientific instrument and equipment development project", the development of scientific instrument industry. Good environment, coupled with policy Dongfeng, the domestic instrument industry continue to force, can be successful in the market "fengeng". Domestic instrument companies need the guidance of the government, the need for policy and financial support. In addition to build more platforms, but also to guide enterprises to seek the development of differentiation. In addition, China should strengthen the support of tax and financial policies for high-tech enterprises, from the tax aspects of domestic equipment companies to give support, and truly implement. In response to the lack of talent in the industry, the government should provide personnel support for the cultivation of talents to provide a series of preferential policies. Although government guidance and national support is very important, but the enterprise is the real subject. Therefore, to take the "12th Five Year" opportunity to break through the plight of the market, domestic enterprises should have a clear positioning and direction of development, rather than blindly expand the scale. Enterprise to long-term development, we can not ignore the quality of the problem, it is necessary to develop more reliable, environmentally friendly, convenient and so on, in order to truly win the favor of consumers. Instrument of domestic enterprises through mergers and acquisitions, strengthen the application research, product focus adjustment, pay attention to the instrument, create their own brands, to develop the international market etc. initiatives, will certainly be able to seize the opportunities for the "Twelfth Five Year Plan", to promote the great development of domestic instrument industry, and in the market and the import of equipment competition, the realization of domestic instrument industry real prosperity and development.